Endocrine Abstracts

Ipilimumab is an immunomodulating agent for the treatment of metastatic melanoma. Ipilimumab is a human mAb which works by inhibiting cytotoxic T-lymphocyte antigen 4 (CTLA-4).CTLA4 typically works to down-regulate the T-cell response and protects self-antigens from recognition by the immune system. Since the T-cells are no longer down-regulated by this antigen, they are allowed to proliferate, thereby helping to prevent melanoma tumor evasion. As a resu...